Sodium Acetate BP USP IP Manufacturers

Anmol Chemicals is the pioneer manufacturers of Sodium Acetate, Pharmaceutical Excipients Fragrance & Flavor chemicals in India. We offer Halal and Kosher Sodium Acetate made in an ISO9001, ISO22000 (FSSC22000), cGMP and GLP cGMP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, Africa, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Sodium Acetate is in these pages.

The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

Sodium Acetate BP USP IP Manufacturers

CAS: 127-09-3 (Anhydrous), 6131-90-4 (Trihydrate), Chemical Formula: CH3COO-Na for Anhydrous, Molecular Weight: 82

Sodium Acetate USP Specifications

Assay— Sodium Acetate contains three molecules of water of hydration, or is anhydrous. It contains not less than 99.0 percent and not more than 101.0 percent of C2H3NaO2, calculated on the dried basis.
Packaging and storage— Preserve in tight containers.
Labeling— Label it to indicate whether it is the trihydrate or is anhydrous. Where Sodium Acetate is intended for use in hem dialysis, it is so labeled.
Identification— A solution responds to the test for Sodium and for Acetate.
pH: between 7.5 and 9.2, in a solution in carbon dioxide-free water containing the equivalent of 30 mg of anhydrous sodium acetate per mL.
Loss on drying— Dry at 120 to constant weight: the hydrous form loses between 38.0% and 41.0% of its weight, and the anhydrous form loses not more than 1.0% of its weight.
Insoluble matter— Dissolve the equivalent of 20 g of anhydrous sodium acetate in 150 mL of water, heat to boiling, and digest in a covered beaker on a steam bath for 1 hour. Filter through a tarred filtering crucible, wash thoroughly, and dry at 105 : the weight of the residue does not exceed 10 mg (0.05%).
Chloride— A portion equivalent to 1.0 g of anhydrous sodium acetate shows no more chloride than corresponds to 0.50 mL of 0.020 N hydrochloric acid (0.035%).
Sulfate— A portion equivalent to 10 g of anhydrous sodium acetate shows no more sulfate than corresponds to 0.50 mL of 0.020 N sulfuric acid (0.005%).
Calcium and magnesium— To 20 mL of a solution containing the equivalent of 10 mg of anhydrous sodium acetate per mL add 2 mL each of 6 N ammonium hydroxide, ammonium oxalate TS, and dibasic sodium phosphate TS: no turbidity is produced within 5 minutes.
Potassium— Dissolve the equivalent of 3 g of anhydrous sodium acetate in 5 mL of water, add 1N acetic acid drop wise until the solution is slightly acidic, and then add 5 drops of sodium cobalt nitrite TS: no precipitate is formed.
Aluminum: (where it is labeled as intended for use in hem dialysis)— the limit is 0.2µ =g per g.
Heavy metals—the limit is 0.001%.
Organic volatile impurities: meets the requirements.

Sodium Acetate Trihydrate BP Specifications

Sodium Acetate BP
C2H3NaO2,3H2O
Action and use
Used in solutions for dialysis; excipient.

DEFINITION
Sodium ethanoate trihydrate.
Content
99.0 per cent to 101.0 per cent (dried substance).

CHARACTERS
Appearance
Colourless crystals.
Solubility
Very soluble in water, soluble in ethanol (96 per cent).

IDENTIFICATION
A. 1 ml of solution S (see Tests) gives reaction (b) of acetates.
B. 1 ml of solution S gives reaction (a) of sodium.
C. Loss on drying (As shown in the Relevant Test).

TESTS
Solution S
Dissolve 10.0 g in carbon dioxide-free water prepared from distilled water R and dilute to 100 ml 100 ml with the same solvent.
Appearance of solution
Solution S is clear and colourless.
pH
7.5 to 9.0.
Dilute 5 ml of solution S to 10 ml with carbon dioxide-free water.
Reducing substances
Dissolve 5.0 g in 50 ml of water, then add 5 ml of dilute sulphuric acid and 0.5 ml of 0.002 M potassium permanganate. The pink colour persists for at least 1 h. Prepare a blank in the same manner but without the substance to be examined.
Chlorides
Maximum 200 ppm.
Sulphates
Maximum 200 ppm.
Aluminium
Maximum 0.2 ppm, if intended for use in the manufacture of dialysis solutions.
Arsenic
Maximum 2 ppm, determined on 0.5 g.
Calcium and magnesium
Maximum 50 ppm, calculated as Ca.
Heavy metals
Maximum 10 ppm.
Iron
Maximum 10 ppm, determined on 10 ml of solution S.
Loss on drying
39.0 per cent to 40.5 per cent, determined on 1.000 g by drying in an oven at 130C.

PARTICULARS	SODIUM ACETATE IP GRADE
Dry Basis Assay	99 to 101%
Characteristics	Colourless Crystals
Solubility	Soluble in 0.8 part of water and in 19 parts of Ethanol (96%)
Clarity and colour of 10% w/v solution	Clear and Colourless
Alkalinity (pH of 5% solution)	7.5-9.0
Arsenic	2 ppm
Calcium and Magnesium (calculated as Ca)	50 ppm
Heavy Metals as Lead	10 ppm
Iron	10 ppm
Chloride	200 ppm
Sulphate	200 ppm
Reducing Substances	Passes test
Packing	In 50 Kg HDPE bag with HMHDPE liner

We offer Sodium Acetate IP BP USP Ph Eur and Extra Pure from our world class FDA approved, ISO-9001-2008 ISO-22000-2005 Certified facility

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564. FAX: 91-22-23728264

Exports to USA, Canada, UAE, Dubai, South Africa, Tanzania, Kenya, Nigeria, Egypt, Uganda, Turkey, Mexico, Brazil, Chile, Argentina, Europe Netherlands, Italy, Spain, Germany, Portugal, France, Malaysia, Indonesia, Thailand, Korea, Vietnam, Japan, etc.