|
Specificaitons |
SODIUM ACETATE
ANHYDROUS PURE
|
SODIUM ACETATE
ANHYDROUS TECHNICAL |
|
Purity
Sodium acetate |
99 % minimum purity as
CH3COONa
|
98.5% minimum purity as
CH3COONa
|
|
Appearance |
Snow-White Powder |
White to Off-White Powder |
|
Clarity of 10% Solution |
A 10% Solution w/v is clear and
colourless |
A 10% Solution w/v is clear |
|
pH (10%
Sod. Acetate
in water) |
pH between 7.5-9 |
pH between 7.5-9 |
|
Arsenic |
Arsenic < 1ppm. |
Arsenic < 1ppm. |
|
Calcium and Magnesium
|
Calcium and magnesium to pass 50 ppm
test |
Calcium and magnesium to pass 100 ppm
test |
|
Heavy Metals |
Heavy Metals < 1ppm |
Heavy Metals < 1ppm |
|
Iron |
Iron < 5ppm |
Iron < 5ppm |
|
Chloride |
Chloride < 250ppm |
Chloride < 1000ppm |
|
Sulphate < 225ppm |
Sulphate < 200ppm |
Sulphate < 500ppm |
|
Packing
of Sodium Acetate |
As required |
As required |
We offer Sodium Acetate IP, Sodium Acetate
BP, Sodium Acetate
USP
or Extra Pure made at our FDA approved world class plant Anmol Chemicals an
ISO-9001-2008 Certified Company using standard GMP techniques
Sodium Acetate BP USP IP ACS AR Analytical
Reagent Food Grade
Sodium Acetate Indian Pharmacopoeia IP Grade Crystals
|
Particulars
|
Sodium
Acetate IP
|
|
Dry Basis Assay
|
99
to 101%
Sodium acetate
|
|
Characteristics
|
Colourless Crystals
|
|
Solubility
|
Soluble
in 0.8 part of water and in 19 parts of Ethanol
(96%)
|
|
Clarity
and colour of 10% w/v solution
|
Clear
and Colourless
|
|
Alkalinity
(pH of 5% solution)
|
7.5-9.0
|
|
Arsenic
|
2
ppm
|
|
Calcium
and Magnesium (calculated as Ca)
|
50
ppm
|
|
Heavy
Metals as Lead
|
10
ppm
|
|
Iron
|
10
ppm
|
|
Chloride
|
200
ppm
|
|
Sulphate
|
200
ppm
|
|
Reducing
Substances
|
Passes
test
|
|
Packing
|
In
50 Kg HDPE bag with HMHDPE liner
|
Sodium Acetate United States Pharmacopoeia USP
|
Particulars
|
Sodium
Acetate USP
|
|
Dry Basis Assay
|
99
to 101%
Sodium acetate
|
|
Characteristics
|
Colourless Crystals
|
|
Solubility
|
Soluble
in 0.8 part of water and in 19 parts of Ethanol
(96%)
|
|
Clarity
and colour of 10% w/v solution of Sodium
Acetate
|
Clear
and Colourless
|
|
Alkalinity
(pH of 5% solution)
|
7.5-9.0
|
|
Arsenic
|
2
ppm
|
|
Calcium
and Magnesium (calculated as Ca)
|
50
ppm
|
|
Heavy
Metals as Lead
|
10
ppm
|
|
Iron
|
10
ppm
|
|
Chloride
|
200
ppm
|
|
Sulphate
|
200
ppm
|
|
Reducing
Substances
|
Passes
test
|
|
Packing
|
In
50 Kg HDPE bags with HMHDPE liner
|
Sodium Acetate:
Sodium acetate, (also sodium ethanoate) is the
sodium salt of acetic acid. It is an
inexpensive chemical produced in industrial quantities for a wide range of
uses.
Applications
|
Sodium
acetate |
|
IUPAC name
|
sodium acetate (IUPAC)
sodium ethanoate (systematic)
|
|
Other names |
sodium salt |
|
Identifiers
|
|
CAS number |
127-09-3 (anhydrous)
6131-90-4 (trihydrate)
|
|
Properties
|
|
Molecular formula |
CH3COONa |
|
Molar mass |
82.03 g/mol (anhydrous)
136.08 g/mol (trihydrate) |
|
Appearance |
White deliquescent powder |
|
Density |
1.45 g/cm³, solid |
|
Melting point |
Decomposes at 324 °C |
|
Boiling point |
Decomposes |
|
Solubility in water |
76 g/100 ml (0°C) |
|
Basicity (pKb)
|
9.25 |
Sodium acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photoresist while using aniline dyes. It is also a pickling agent in chrome tanning, and it helps to retard vulcanization of chloroprene in synthetic rubber production.
It is the chemical that gives salt and vinegar chips (crisps) their flavor. It may also be
added to foods as a preservative; in this application it is usually written as
"sodium diacetate" and labeled E262.
As the conjugate base of a weak acid, a solution of sodium acetate and
acetic acid can act as a buffer to keep a relatively constant pH. This is useful especially in biochemical
applications where reactions are pH dependent.
Traditional applications of Sodium Acetate buffering agent include
the leather tanning and dye industries. It is used in TANNING to effect a more even and rapid penetration of the tan. In
the TEXTILE industry, it is considered a dye
and color intermediate, with specific use as a mordant in the dyeing
process. Because of its ability to remove insoluble calcium salts, it is further used by the textile industry to improve the wearing
quality of finished fabrics.
It is considered one of the best agents
available for the neutralization of mineral acids. It is commonly used in
SOAP MAKING.
The FOOD industry relies on sodium acetate
as a buffer in controlling pH of food items during various stages of
processing as well as for the finished consumable item. It is
also used as a flavor enhancer in meat and poultry.
It may be added to foods as a
seasoning, and to alcoholic beverages to
decrease the risk of a hangover.
As the conjugate base of a weak acid, a
solution of sodium acetate and acetic acid
can act as a BUFFER SOLUTION to keep a
relatively constant pH. This is useful
especially in biochemical applications where
reactions are pH dependent.
The COSMETICS industry also values a good
buffering agent, so it uses sodium acetate in a wide variety of personal
care items.
In PLASTICS manufacturing, sodium acetate
is used as a retarder for elastomers (polymers with elastic properties of
rubber). The PHOTOGRAPHIC industry traditionally included
sodium acetate in its developer formula.
Newer applications of sodium acetate include its use as a
carbon source in WATER TREATMENT. Acetate is a safe and
environmentally-friendly alternative to hazardous methanol for the
denitrification of wastewater.
The PETROLEUM industry relies on it as a buffering agent in petroleum production, drilling muds, and
completion fluids.
It is also used in consumer HEATING PADS
or hand warmers and is also used in hot ice. Sodium acetate trihydrate
crystals melt at 58 °C, dissolving in their water of crystallization. When
they are heated to around 100 °C, and subsequently allowed to cool, the
aqueous solution becomes supersaturated. This solution is capable of
supercooling to room temperature without forming crystals. By clicking on a
metal disc in the heating pad, a nucleation center is formed which causes
the solution to crystallize into solid trihydrate crystals again. The
bond-forming process of crystallization is exothermic, hence heat is
emitted. The latent heat of fusion is about 264–289 kJ/kg. Unlike some other
types of heat packs that depend on irreversible chemical reactions, sodium
acetate heat packs can be easily recharged by boiling until all crystals are
dissolved. Therefore they can be recycled indefinitely.
The MEDICAL & PHARMACEUTICAL industry uses
it in formula for diuretic expectorants and systemic alkalizers.
It is commonly used in dry blends for renal dialysis. The heat of
crystallization generated by sodium acetate is widely and effectively used
in the heat pack industry.
Another new application of this versatile chemical is in
poultry farming. It is added to drinking water for chickens to
help prevent disease conditions associated with overheating and dehydration.
It is widely used in de-icer products, especially at airports
It is also used as a buffer in petroleum production, and for kidney
dialysis processes.
All in all, it indeed is a remarkable chemical
with applications span a wide range of industries.
Clinical Pharmacology
Sodium is the
principal cation of
extracellular fluid. It
comprises more than 90% of total
cations at its normal plasma
concentration of approximately
140 mEq/liter. The sodium ion
exerts a primary role in
controlling total body water and
its distribution.
Acetate (CH3COO−
), a source of hydrogen ion
acceptors, is an alternate
source of bicarbonate (HCO3−)
by metabolic conversion in the
liver. This has been shown to
proceed readily, even in the
presence of severe liver
disease.
Indications and Usage for Sodium Acetate
Sodium Acetate Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions.
Contraindications
Sodium Acetate Injection, USP 40 mEq is contraindicated in patients with hypernatremia or fluid retention.
Warnings
Sodium Acetate Injection, USP 40 mEq must be diluted before use.
To avoid sodium overload and water retention, infuse sodium-containing solutions slowly.
Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention.
In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention.
Solutions containing acetate ions should be used with great care in patients with metabolic or respiratory alkalosis. Acetate should be administered with great care in those conditions in which there is an increased level or an impaired utilization of this ion, such as severe hepatic insufficiency.
The intravenous administration of this solution (after appropriate dilution) can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states or pulmonary edema. Excessive administration of potassium free solutions may result in significant hypokalemia.
WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
Precautions
Do not administer unless solution is clear and seal is intact. Discard unused portion.
Sodium replacement therapy should be guided primarily by the serum sodium level.
Caution should be exercised in administering sodium-containing solutions to patients with severe renal function impairment, cirrhosis, cardiac failure, or other edematous or sodium-retaining states, as well as in patients with oliguria or anuria.
Caution must be exercised in the administration of parenteral fluids, especially those containing sodium ions, to patients receiving corticosteroids or corticotropin.
Solutions containing acetate ions should be used with caution as excess administration may result in metabolic alkalosis.
Pregnancy Category C.
Animal reproduction studies have not been conducted with Sodium Acetate. It is also not known whether Sodium Acetate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sodium Acetate should be given to a pregnant woman only if clearly needed.
Pediatric Use:
Safety and effectiveness have been established in the age groups infant to adolescent.
Geriatric Use:
An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Sodium ions are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Adverse Reactions
Sodium overload can occur with intravenous infusion of excessive amounts of sodium-containing solutions. See WARNINGS and PRECAUTIONS.
Overdosage
In the event of overdosage, discontinue infusion containing Sodium Acetate immediately and institute corrective therapy as indicated to reduce elevated serum sodium levels, and restore acid-base balance if necessary.
Dosage and Administration
Sodium Acetate Injection, USP 40 mEq is administered intravenously only after dilution in a larger volume of fluid. The dose and rate of administration are dependent upon the individual needs of the patient. Serum sodium should be monitored as a guide to dosage. Using aseptic technique, all or part of the contents of one or more vials may be added to other intravenous fluids to provide any desired number of milliequivalents (mEq) of sodium (Na+) with an equal number of acetate (CH3COO−).
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.
Preparation
It is sometimes produced in a laboratory experiment by the reaction of
acetic
acid with sodium carbonate, sodium bicarbonate, or sodium hydroxide. These reactions produce sodium acetate (aq), water, and carbon
dioxide, which leaves the reaction vessel as a gas, is produced by the first
two.
CH3–COOH + Na+[HCO3]– → CH3–COO– Na+ + H2O +
CO2
This is the well-known "fizzing" reaction between baking
soda and vinegar. 84 grams of sodium bicarbonate react
with 750 g of 8% vinegar to make 82 g sodium acetate in water. By subsequently
boiling off most of the water, one can refine either a concentrated solution of
sodium acetate or actual crystals.
Reactions
Sodium acetate can be used to form an ester with an alkyl
halide such as bromoethane:
H3C–COO–
Na+ + Br–CH2–CH3 → H3C–COO–CH2–CH3
+ NaBr
In such a reaction, the sodium acetate is usually
complexed with caesium in order to increase the nucleophilicity of the
carboxylate group.
SODIUM ACETATE MSDS
1. Product Identification
Synonyms:
Sodium acetate trihydrate; Acetic acid, sodium salt trihydrate
CAS No.: 127-09-3 (Anhydrous); 6131-90-4 (Trihydrate)
Molecular Weight: 136.08
Chemical Formula: CH3COONa 3H2O
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------
Sodium Acetate 127-09-3 99 - 100% Yes
3. Hazards Identification
Emergency
Overview
--------------------------
CAUTION! MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
-----------------------------------------------------------------------------------------------------------
Health Rating: 1 - Slight
Flammability Rating: 0 - None
Reactivity Rating: 0 - None
Contact Rating: 1 - Slight
Lab Protective Equip: GOGGLES; LAB COAT
Storage Color Code: Orange (General Storage)
-----------------------------------------------------------------------------------------------------------
Potential Health Effects
----------------------------------
Inhalation:
It may cause irritation to the respiratory tract. Symptoms may
include coughing, sore throat, labored breathing, and chest pain.
Ingestion:
Large doses may produce abdominal pain, nausea, and vomiting.
Skin Contact:
It may cause irritation with redness and pain.
Eye Contact:
Contact may cause irritation, redness, and pain.
Chronic Exposure:
No information found.
Aggravation of Pre-existing Conditions:
No information found.
4. First Aid Measures
Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Give several glasses of water to drink to dilute. If large amounts were
swallowed, get medical advice.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes. Remove
contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean
shoes before reuse. Get medical attention if irritation develops.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
upper and lower eyelids occasionally. Get medical attention if irritation
persists.
5. Fire Fighting Measures
Fire:
Autoignition temperature: 611C (1132F). As with most organic solids, fire is
possible at elevated temperatures or by contact with an ignition source. Listed
fire data is for the Anhydrous Material.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of
an ignition source is a potential dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the pressure
demand or other positive pressure mode.
6. Accidental Release Measures
Remove all sources of ignition. Ventilate area of leak or spill. Wear
appropriate personal protective equipment as specified in Section 8. Spills:
Clean up spills in a manner that does not disperse dust into the air. Use
non-sparking tools and equipment. Reduce airborne dust and prevent scattering by
moistening with water. Pick up spill for recovery or disposal and place in a
closed container. Small amounts of residue of Sodium acetate may be flushed to
sewer with plenty of water.
7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area.
Protect Sodium acetate against physical damage. Isolate from any
source of heat or ignition. Containers may be hazardous when
empty since they retain product residues (dust, solids); observe all warnings
and precautions listed for the product.
8. Exposure Controls/Personal Protection
Airborne
Exposure Limits:
None established.
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures as low as possible. Local exhaust ventilation is generally preferred
because it can control the emissions of the contaminant at its source,
preventing dispersion of it into the general work area. Please refer to the
ACGIH document, Industrial Ventilation, A Manual of Recommended Practices,
most recent edition, for details.
Personal Respirators (NIOSH Approved):
For conditions of use where exposure to dust or mist is apparent and engineering
controls are not feasible, a particulate respirator (NIOSH type N95 or better
filters) may be worn. If oil particles (e.g. lubricants, cutting fluids,
glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or
instances where the exposure levels are not known, use a full-face
positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators
do not protect workers in oxygen-deficient atmospheres.
Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drench
facilities in work area.
9. Physical and Chemical Properties
Appearance:
Colorless crystals.
Odor:
It has slight acetic acid odor.
Solubility:
The solubility is 76 gm/100mls water @ 0C
Density:
It has specific gravity of 1.45
pH:
8.9
% Volatiles by volume @ 21C (70F):
0
Boiling Point:
Not applicable.
Melting Point:
Loses water @ 120C (248F); decomposes @ 324C (615.2F)
Vapor Density (Air=1):
No information found.
Vapor Pressure (mm Hg):
No information found.
Evaporation Rate (BuAc=1):
No information found.
10. Stability and Reactivity
Stability:
SIt is stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
It emits fumes of acetic acid upon heating and on contact with
strong acids.
Hazardous Polymerization: Will not occur.
Incompatibilities:
Nitric acid, fluoride, potassium nitrate, strong oxidizers and diketene.
Conditions to Avoid:
Incompatibles.
11. Toxicological Information
Hydrate:
Investigated as a mutagen. Anhydrous: Oral rat LD50: 3530 mg/kg; inhalation rat
LC50: > 30 gm/m3; skin rabbit LD50: > 10 mg/kg; Irritation Data, standard Draize:
Skin rabbit 500 mg/24H, mild; standard Draize, Eye rabbit 10 mg, mild.
Investigated as a mutagen.
12. Ecological Information
Environmental Fate:
No information found.
Environmental Toxicity:
No information found.
13. Disposal Considerations
Whatever
cannot be saved for recovery or recycling should be managed in an appropriate
and approved waste disposal facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and
local requirements.
14. Transport Information
Not
regulated.
15. Regulatory Information
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No
Reactivity: No (Pure / Solid)
Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:
This Sodium acetate MSDS has been prepared according to the hazard criteria of the Controlled
Products Regulations (CPR) and the MSDS contains all of the information required
by the CPR.
16. Other Information
NFPA
Ratings: Health: 1 Flammability: 1 Reactivity: 0
Label Hazard Warning:
CAUTION! MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
Avoid contact with eyes, skin and clothing.
Avoid breathing dust.
Use with adequate ventilation.
Wash thoroughly after handling.
Keep container closed.
Label First Aid:
If inhaled, remove to fresh air. Get medical attention for any breathing
difficulty. In case of contact, immediately flush eyes or skin with plenty of
water for at least 15 minutes. Get medical attention if irritation develops or
persists.
Disclaimer:
***************************************************************************************************
Our company provides this MSDS information contained
herein in good faith but makes no representation as to its comprehensiveness or
accuracy. This MSDS document is intended only as a guide
to the appropriate precautionary handling of the material by a properly trained
person using this product. Individuals receiving the information must exercise
their independent judgment in determining its appropriateness for a particular
purpose.
***************************************************************************************************
More from Sodium Acetate
manufacturer at:
MUBY CHEMICALS
S-8,
SARIFA
MANSION,
2ND
FLANK ROAD,
CHINCHBUNDER, MUMBAI 400009,
INDIA.
TEL: (OFFICE) 91-22-23770100,
23774610, 23726950, 23723564. FAX: 91-22-23728264.
Email:
info@mubychem.com
Cell Call to
Anmol: +91-9821870100 or Ambrish:
+91-9821570100
Copyright
and Usual Disclaimer
is Applicable.
Last updated:
04 February, 2010.
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