(FDA) GMP Approved ISO-9001:2008 Certificate "REACH" Pre-registered ISO-22000:2005 Kosher Certified Halal Certified HACCP	Mubychem Group, established in 1976, is the pioneer manufacturer of Zinc Chloride, Ammonium Chloride, Calcium Chloride, Potassium Chloride, Sodium Acetate, Sodium Thiosulphate or Sodium Thiosulfate and various other chemicals in India.  Mubychem Group has manufacturing facilities spread across Western India.	For Translating this page in your language use this translation tool.
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Sodium Acetate Manufacturers Anhydrous Trihydrate

CAS: 127-09-3 (Sodium Acetate Anhydrous); 6131-90-4 (Sodium Acetate Trihydrate)
Chemical Formula: CH3COO-Na for Anhydrous
Molecular Weight: 82

Sodium Acetate BP USP ACS AR
For MSDS Sheet Click MSDS

Sodium Acetate
Anhydrous, Powder, Crystals, Trihydrate
IP BP Ph. Eur. USP ACS AR LR Food Grade

GRADES AND SPECIFICATIONS OF SODIUM ACETATE TRI-HYDRATE CRYSTALS

SPECIFICATIONS	SODIUM ACETATE TRIHYDRATE PURE	SODIUM ACETATE TRIHYDRATE TECHNICAL
Assay	99%  Sodium Acetate Trihydrate minimum	98% Sodium Acetate Trihydrate minimum
Appearance	White Transparent Crystalline	Off-White Crystalline
Test Solution	A 10% Solution is clear & colourless	A 10% Solution is clear & colourless
pH	7.5-9	7.5-9
Arsenic	Less than 1 ppm	Less than 1 ppm
Calcium & Magnesium	Less than 50 ppm	Less than 100 ppm
Heavy Metals	Less than 1 ppm	Less than 10 ppm
Iron	Less than 5ppm	Less than 10 ppm
Chlorides	Less than 0.03%	Less than 0.5%
Sulphates	Less than 0.02%	Less than 0.5%
Packing	As required	As required

 

GRADES AND SPECIFICATIONS OF SODIUM ACETATE ANHYDROUS POWDER.

SPECIFICATIONS	SODIUM ACETATE ANHYDROUS PURE	SODIUM ACETATE ANHYDROUS TECHNICAL
Purity	99 % minimum purity as CH3COONa	98.5% minimum purity as CH3COONa
Appearance	Snow-White Powder	White to Off-White Powder
Clarity of 10% Solution	A 10% Solution w/v is clear and colourless	A 10% Solution w/v is clear
pH (10% in water)	pH between 7.5-9	pH between 7.5-9
Arsenic	Arsenic < 1ppm.	Arsenic < 1ppm.
Calcium and Magnesium	To pass the test 50 ppm	To pass the test 100 ppm
Heavy Metals	Heavy Metals < 1ppm	Heavy Metals < 10ppm
Iron	Iron < 5ppm	Iron < 10ppm
Chloride	Chloride < 100ppm	Chloride <0.5%
Sulphate < 225ppm	Sulphate < 20ppm	Sulphate <0.5%
Packing	25kg(55 lbs)-50kg bags or pellets or as required

 

We offer Sodium Acetate IP, Sodium Acetate BP, Sodium Acetate USP or Extra Pure made at our FDA approved world class plant Anmol Chemicals an ISO-9001-2008 Certified Company using standard GMP techniques

 

Sodium Acetate USP BP IP ACS AR Grade Analytical Reagent Food Grade

 

Sodium Acetate IP Pharma Grade

Particulars	IP Grade
Dry Basis Assay	99 to 101%
Characteristics	Colourless Crystals
Solubility	Soluble in 0.8 part of water and in 19 parts of Ethanol (96%)
Clarity and colour of  10% w/v solution	Clear and Colourless
Alkalinity (pH of 5% solution)	7.5-9.0
Arsenic	2 ppm
Calcium and Magnesium (calculated as Ca)	50 ppm
Heavy Metals as Lead	10 ppm
Iron	10 ppm
Chloride	200 ppm
Sulphate	200 ppm
Reducing Substances	Passes test
Packing	In 50 Kg HDPE bag with HMHDPE liner

 

Sodium Acetate USP United States Pharmacopoeia Grade

Particulars	USP Grade
Dry Basis Assay	99 to 101%
Characteristics	Colourless Crystals
Solubility	Soluble in 0.8 part of water and in 19 parts of Ethanol (96%)
Clarity and colour of  10% w/v solution	Clear and Colourless
Alkalinity (pH of 5% solution)	7.5-9.0
Arsenic	2 ppm
Calcium and Magnesium (calculated as Ca)	50 ppm
Heavy Metals as Lead	10 ppm
Iron	10 ppm
Chloride	200 ppm
Sulphate	200 ppm
Reducing Substances	Passes test
Packing	In 50 Kg HDPE bags with HMHDPE liner

Sodium acetate, (also sodium ethanoate) is the sodium salt of acetic acid. It is an inexpensive chemical produced in industrial quantities for a wide range of uses.

Applications

Sodium acetate is used in the textile industry to neutralize sulfuric acid waste streams, and as a photo resist while using aniline dyes. It is also a pickling agent in chrome tanning, and it helps to retard vulcanization of chloroprene in synthetic rubber production.It is the chemical that gives salt and vinegar chips (crisps) their flavor. It may also be added to foods as a preservative; in this application it is usually written as "sodium diacetate" and labeled E262.Traditional applications of Sodium Acetate buffering agent include the leather tanning and dye industries. It is used in TANNING to effect a more even and rapid penetration of the tan. In the TEXTILE industry, it is considered a dye and color intermediate, with specific use as a mordant in the dyeing process. Because of its ability to remove insoluble calcium salts, it is further used by the textile industry to improve the wearing quality of finished fabrics. It is considered one of the best agents available for the neutralization of mineral acids. It is commonly used in SOAP MAKING. The FOOD industry relies on sodium acetate as a buffer in controlling pH of food items during various stages of processing as well as for the finished consumable item. It is also used as a flavor enhancer in meat and poultry. It may be added to foods as a seasoning, and to alcoholic beverages to decrease the risk of a hangover. As the conjugate base of a weak acid, a solution of sodium acetate and acetic acid can act as a BUFFER SOLUTION to keep a relatively constant pH. This is useful especially in biochemical applications where reactions are pH dependent. The COSMETICS industry also values a good buffering agent, so it uses sodium acetate in a wide variety of personal care items. In PLASTICS manufacturing, sodium acetate is used as a retarder for elastomers (polymers with elastic properties of rubber). The PHOTOGRAPHIC industry traditionally included sodium acetate in its developer formula. Newer applications of sodium acetate include its use as a carbon source in WATER TREATMENT. Acetate is a safe and environmentally-friendly alternative to hazardous methanol for the de-nitrification of wastewater. The PETROLEUM industry relies on it as a buffering agent in petroleum production, drilling Muds, and completion fluids. It is also used in consumer HEATING PADS or hand warmers and is also used in hot ice. Sodium acetate trihydrate crystals melt at 58 °C, dissolving in their water of crystallization. When they are heated to around 100C, and subsequently allowed to cool, the aqueous solution becomes supersaturated. This solution is capable of super cooling to room temperature without forming crystals. By clicking on a metal disc in the heating pad, a nucleation center is formed which causes the solution to crystallize into solid trihydrate crystals again. The bond-forming process of crystallization is exothermic, hence heat is emitted. The latent heat of fusion is about 264–289 kJ/kg. Unlike some other types of heat packs that depend on irreversible chemical reactions, sodium acetate heat packs can be easily recharged by boiling until all crystals are dissolved. Therefore they can be recycled indefinitely. The MEDICAL & PHARMACEUTICAL industry uses it in formula for diuretic expectorants and systemic alkalizers. It is commonly used in dry blends for renal dialysis. The heat of crystallization generated by sodium acetate is widely and effectively used in the heat pack industry.

Another new application of this versatile chemical is in poultry farming. It is added to drinking water for chickens to help prevent disease conditions associated with overheating and dehydration.

It is widely used in de-icer products, especially at airports

It is also used as a buffer in petroleum production, and for kidney dialysis processes.

All in all, it indeed is a remarkable chemical with applications span a wide range of industries.

Clinical Pharmacology

Sodium is the principal cation of extra cellular fluid. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. The sodium ion exerts a primary role in controlling total body water and its distribution.

Acetate (CH3COO− ), a source of hydrogen ion acceptors, is an alternate source of bicarbonate (HCO3−) by metabolic conversion in the liver. This has been shown to proceed readily, even in the presence of severe liver disease.

Indications and Usage for Sodium Acetate

Sodium Acetate Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions.

Contraindications

Sodium Acetate Injection, USP 40 mEq is contraindicated in patients with hypernatremia or fluid retention.

Warnings

Sodium Acetate Injection, USP 40 mEq must be diluted before use.

To avoid sodium overload and water retention, infuse sodium-containing solutions slowly.

Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention.

In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention.

Solutions containing acetate ions should be used with great care in patients with metabolic or respiratory alkalosis. Acetate should be administered with great care in those conditions in which there is an increased level or an impaired utilization of this ion, such as severe hepatic insufficiency.

The intravenous administration of this solution (after appropriate dilution) can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states or pulmonary edema. Excessive administration of potassium free solutions may result in significant hypokalemia.

WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Precautions

Do not administer unless solution is clear and seal is intact. Discard unused portion.

Sodium replacement therapy should be guided primarily by the serum sodium level.

Caution should be exercised in administering sodium-containing solutions to patients with severe renal function impairment, cirrhosis, cardiac failure, or other edematous or sodium-retaining states, as well as in patients with oliguria or anuria.

Caution must be exercised in the administration of parenteral fluids, especially those containing sodium ions, to patients receiving corticosteroids or corticotropin.

Solutions containing acetate ions should be used with caution as excess administration may result in metabolic alkalosis.

Pregnancy Category C

Animal reproduction studies have not been conducted with Sodium Acetate. It is also not known whether Sodium Acetate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sodium Acetate should be given to a pregnant woman only if clearly needed.

Pediatric Use:

Safety and effectiveness have been established in the age groups infant to adolescent.

Geriatric Use:

An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Sodium ions are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Adverse Reactions

Sodium overload can occur with intravenous infusion of excessive amounts of sodium-containing solutions. See WARNINGS and PRECAUTIONS.

Over dosage

In the event of over dosage, discontinue infusion containing Sodium Acetate immediately and institute corrective therapy as indicated to reduce elevated serum sodium levels, and restore acid-base balance if necessary.

Dosage and Administration

Sodium Acetate Injection, USP 40 mEq is administered intravenously only after dilution in a larger volume of fluid. The dose and rate of administration are dependent upon the individual needs of the patient. Serum sodium should be monitored as a guide to dosage. Using aseptic technique, all or part of the contents of one or more vials may be added to other intravenous fluids to provide any desired number of milliequivalents (mEq) of sodium (Na+) with an equal number of acetate (CH3COO−).

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

Preparation

It is sometimes produced in a laboratory experiment by the reaction of acetic acid with sodium carbonate, sodium bicarbonate, or sodium hydroxide. These reactions produce sodium acetate (aq), water, and carbon dioxide, which leaves the reaction vessel as a gas, is produced by the first two.

CH3–COOH + Na+[HCO3]– → CH3–COO– Na+ + H2O + CO2

This is the well-known "fizzing" reaction between baking soda and vinegar. 84 grams of sodium bicarbonate react with 750 g of 8% vinegar to make 82 g sodium acetate in water. By subsequently boiling off most of the water, one can refine either a concentrated solution of sodium acetate or actual crystals.

Reactions

Sodium acetate can be used to form an ester with an alkyl halide such as bromoethane:

H3C–COO– Na+ + Br–CH2–CH3 → H3C–COO–CH2–CH3 + NaBr

In such a reaction, the sodium acetate is usually complexed with caesium in order to increase the nucleophilicity of the carboxylate group.

Sodium Acetate Anhydrous
Sodium Acetate Trihydrate
Sodium Acetate manufacturers at:

MUBY CHEMICALS
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564. FAX: 91-22-23728264

e-mail: info@mubychem.com

Cell Call to Anmol: +91-9821870100
USA & Canadian Customers may Call 773-829-5811

Copyright and Usual Disclaimer is Applicable
Last updated: 05 January, 2012

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